Clinical management of calcified teeth provides an endodontic treatment challenge and makes up a significant portion of current endodontic practice. Searching for calcified root canals can be challenging and, time-consuming and may create a huge loss of tooth structure that is associated with a high risk of fracture and perforation, compromising the prognosis of the tooth. Nowadays, the use of new technologies has increased the predictability of the treatment of calcified teeth. A new clinical approach for to a tooth with PCO, called “guided endodontics,” has been introduced. This technique consists in the use of a guiding template, which facilitates the localization of severely calcified root canals. With this lecture will be presented, through clinical cases, this form of approach to face this clinical challenge, providing some tips and tricks to achieve the mechanical and biological goals of endodontic treatment.